Glycosylation in Health and Disease

Glycan glycosylation Protein is the executor of life activities. During the study of protein, researchers find that there are many modifications of the protein. Among these modifications, glycosylation modification is quite common, and more than 50% of the proteins found so far have glycosylation modification. Glycan is the sugar part of glycoprotein, including a sugar…

Top-Down Proteomics vs Bottom-Up Proteomics

Protein research is one of the most challenging topics in analytical chemistry. Initial protein research focused on developing techniques capable of isolating and identifying major sequences (or portions) of proteins. Edman degradation of peptide is a revolutionary method to identify the main amino acid sequence of peptide. In addition, the whole sequence of proteins can…